N‐acetylcysteine as a potentially safe adjuvant in the treatment of neurotoxicity due to pirimiphos‐methyl poisoning.

  • Published In: Basic & Clinical Pharmacology & Toxicology, 2024, v. 135, n. 2. P. 164 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Piotr, Adamczuk; Konrad, Jamka; Hubert, Bojar; Krzysztof, Łukawski; Grzegorz, Raszewski 3 of 3

Abstract

Exogenous, well‐established antioxidant N‐acetylcysteine can reduce or prevent the deleterious effects of pesticides. In this study, utilizing a mouse model of daily single dose of N‐acetylcysteine administration, we investigated the impact of this adjuvant on the treatment with atropine and/or obidoxime as well as oxidative stress response in pyrimiphos‐methyl‐induced toxicity. We found that N‐acetylcysteine significantly reduces the oxidative stress generated by pyrimiphos‐methyl. The therapy consisting of atropine and/or obidoxime routinely used in organophosphorous insecticide poisonings, including pyrimiphos‐methyl, had no effect on the antioxidant properties of N‐acetylcysteine. Adjunctive treatment offered by N‐acetylcysteine fills therapeutic gap and may provide the full potential against pyrimiphos‐methyl‐induced toxicity. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:Basic & Clinical Pharmacology & Toxicology. 2024/08, Vol. 135, Issue 2, p164
  • Document Type:Article
  • Subject Area:Complementary and Alternative Medicine
  • Publication Date:2024
  • ISSN:1742-7835
  • DOI:10.1111/bcpt.14044
  • Accession Number:178442738
  • Copyright Statement:Copyright of Basic & Clinical Pharmacology & Toxicology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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